KIT-KIT Ligand in the Growth of Porcine Oocytes in Primordial Follicles
نویسندگان
چکیده
منابع مشابه
KIT-KIT ligand in the growth of porcine oocytes in primordial follicles.
Mammalian ovaries are endowed with a huge number of small oocytes in primordial follicles (primordial oocytes). The mechanism regulating initiation of oocyte growth and follicular development is not well understood. Several growth factors and cytokines are known to be involved in oocyte growth and follicular development. Herein, the involvement of KIT, a receptor tyrosine kinase, and its ligand...
متن کاملKITLG (KIT ligand)
The membrane bound form is a surface molecule of 248 aa, that includes 23 aa of the highly hydrophobic transmembrane domain; the second form corresponds to a soluble protein constituted by the first 165 aa of the extracellular domain released by a posttranslational processing, consisting in a proteolytic cleavage of the mature SCF in the extracellular juxtamembrane region; the full length trans...
متن کاملRegulation of ovarian folliculogenesis by Kit Ligand and the c-Kit system in mammals
The system comprised of Kit Ligand (KL) and its receptor c-Kit has proven to play a role in normal female reproduction and fertility in mammals. Gene expression studies have revealed that biological activities of ligands and receptors of the KL/c-Kit system are important in controlling apoptosis and cellular proliferation in reproductive tissues. Collectively, these studies have provided a bett...
متن کامل: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes
هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...
Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture.
The receptor tyrosine c-Kit and its cognate ligand, c-Kit ligand (KL, stem cell factor, SCF), are involved in ovarian follicular development in several animal species. We studied the expression of KL and c-Kit using in situ hybridization and immunohistochemistry in donated human ovarian cortical tissue. The KL transcripts were expressed in granulosa cells of primary follicles, whereas the expre...
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ژورنال
عنوان ژورنال: Journal of Reproduction and Development
سال: 2007
ISSN: 0916-8818,1348-4400
DOI: 10.1262/jrd.19107